A once daily dose of DU-176b, a Factor Xa inhibitor, may be a safe alternative to treatment with warfarin in patients with atrial fibrillation, according to the results of a phase-2 study.
“DU-176b is a promising new oral anticoagulant. When used at doses of 30 mg or 60 mg per day DU-176b appears to have a safety profile similar to that of warfarin,” said Jeffrey I. Weitz, MD, Henderson Research Centre, Hamilton, Ontario.
Patients with non-valvular atrial fibrillation with a CHADS2 index >2 were enrolled in the study. Patients were assigned to warfarin or one ...